Research Focus
C. Brostjan has a prime interest in vascular biology and disease, addressing the interplay of leukocytes, platelets and endothelial cells in pro-inflammatory activation, coagulation and angiogenesis. This interplay is primarily investigated in the context of abdominal aortic aneurysms and cancer. The projects include mouse models of disease as well as basic research on gene and protein regulation initiated by the interaction of blood cell populations and endothelial cells. Furthermore, translational studies with blood and tissue analyses are focused on patients with abdominal aortic aneurysm.
1. Natural IgM recognizing oxidation-specific epitopes in abdominal aortic aneurysms
Cardiovascular diseases are characterized by inflammatory processes which result in the modification of molecules, thereby generating so-called oxidation specific epitopes (OSEs). Natural antibodies (IgM) against OSEs have been recognized for their protective effect in atherosclerotic disease. In contrast, little is known about the role of OSE-specific antibodies in abdominal aortic aneurysms (AAAs) which share many features of atherosclerosis. AAA is a progressive dilatation of the abdominal aorta due to the weakening of the vessel wall. It constitutes a serious condition with the risk of aorta rupture and sudden death. Yet, it lacks approved drug treatments and can only be surgically repaired. In the current project we aim to investigate the contribution of OSE IgM to AAA development and their therapeutic potential in mouse models of AAA. Furthermore, OSE IgM are investigated in clinical samples of patients with AAA (FWF P37183-B, collaboration project with Taras Afonyushkin, Dpt. Laboratory Medicine, MUW).
2. Monocyte subsets in cancer
Monocytes represent a heterogeneous population with subsets of distinct phenotype and function. While we have previously found that the so-called “intermediate monocytes” (known to be associated with angiogenesis and tissue remodeling) are elevated in colorectal cancer patients and their rise predicts response to chemotherapy, the current investigations are focused on adoptive transfer of human monocyte subsets in humanized mouse models of colorectal cancer (FWF DOC 59 doc.fund).
Labormitarbeiter:innen/Team
a.o. Univ.-Prof. Dr. Christine BROSTJAN
Priv.Doz. Dr. Wolf EILENBERG, PhD
Hubert HAYDEN, MSc
Technician
Daria ANOKHINA, MD
predoctoral fellow
Lukas FUCHS, MD
predoctoral fellow
Nahla IBRAHIM, MSc
predoctoral fellow
Johannes KLOPF, MD
predoctoral fellow
Maria SAHAGUN CORTEZ
predoctoral fellow
Anna SOTIR, MD
predoctoral fellow
Publikationen
Radiation therapy for cancer is potentially associated with reduced growth of concomitant abdominal aortic aneurysm. Becker von Rose A, Kobus K, Bohmann B, Lindquist-Lilljequist M, Eilenberg W, Kapalla M, Bassermann F, Reeps C, Eckstein HH, Neumayer C, Brostjan C, Roy J, von Heckel K, Hultgren R, Schwaiger BJ, Combs SE, Busch A, Schiller K. Strahlenther Onkol. 2023 Sep 7. doi: 10.1007/s00066-023-02135-0.
Evaluation of national institute for health and care excellence guidance for ruptured abdominal aortic aneurysms by emulating a hypothetical target trial. Eilenberg W, Waduud MA, Davies H, Bailey MA, Scott DJA, Wolf F, Sotir A, Lakowitsch S, Kaider A, Heinze G, Brostjan C, Domenig CM, Neumayer C. Front Cardiovasc Med. 2023 10(1219744. doi: 10.3389/fcvm.2023.1219744.
Quantitation of oxidized nuclear and mitochondrial DNA in plasma samples of patients with abdominal aortic aneurysm. Hayden H, Klopf J, Ibrahim N, Knöbl V, Sotir A, Mekis R, Nowikovsky K, Eilenberg W, Neumayer C, Brostjan C. Free Radic Biol Med. 2023 Sep;206(94-105. doi: 10.1016/j.freeradbiomed.2023.06.014.
Elevated EMMPRIN Serum Levels Indicate Plaque Vulnerability in Patients With Asymptomatic High Grade Carotid Stenosis. Kampf S, Micko A, Stojkovic S, Nackenhorst M, Demyanets S, Eilenberg WH, Krenn C, Wojta J, Neumayer C. Eur J Vasc Endovasc Surg. 2023 Apr;65(4):474-483. doi: 10.1016/j.ejvs.2022.12.010.
MetAAA trial patients show superior quality of life compared to patients under regular surveillance for small AAA: a single-center retrospective cohort study. Klopf J, Willixhofer R, Scheuba A, Fuchs L, Sotir A, Wanhainen A, Brostjan C, Neumayer C, Eilenberg W. Int J Surg. 2023 Apr 1;109(4):861-869. doi: 10.1097/js9.0000000000000343.
Endovascular Repair of Penetrating Thoracic Aortic Ulcers Using Tubular Stent Grafts Versus Stent Grafts With a Proximal Scallop. Kupferthaler A, Hauck SR, Schwarz M, Kern M, Deinsberger J, Dachs TM, Neumayer C, Stelzmüller ME, Ehrlich M, Loewe C, Funovics MA. J Endovasc Ther. 2023 Jan 20:15266028221149919. doi: 10.1177/15266028221149919.
Neutrophils in lung cancer patients: Activation potential and neutrophil extracellular trap formation. Mauracher LM, Hell L, Moik F, Krall M, Englisch C, Roiß J, Grilz E, Hofbauer TM, Brostjan C, Knapp S, Ay C, Pabinger I. Res Pract Thromb Haemost. 2023 Feb;7(2):100126. doi: 10.1016/j.rpth.2023.100126.
Oncogenic Addiction of Fibrolamellar Hepatocellular Carcinoma to the Fusion Kinase DNAJB1-PRKACA. Neumayer C, Ng D, Jiang CS, Qureshi A, Lalazar G, Vaughan R, Simon SM. Clin Cancer Res. 2023 Jan 4;29(1):271-278. doi: 10.1158/1078-0432.Ccr-22-1851.
Toll-like Receptors as Pro-Thrombotic Drivers in Viral Infections: A Narrative Review. Panzer B, Kopp CW, Neumayer C, Koppensteiner R, Jozkowicz A, Poledniczek M, Gremmel T, Jilma B, Wadowski PP. Cells. 2023 Jul 16;12(14). doi: 10.3390/cells12141865.
Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease-Pathophysiology and Translational Therapeutic Approaches. Poledniczek M, Neumayer C, Kopp CW, Schlager O, Gremmel T, Jozkowicz A, Gschwandtner ME, Koppensteiner R, Wadowski PP. Biomedicines. 2023 Aug 17;11(8). doi: 10.3390/biomedicines11082284.
Small cell lung cancer: circulating tumor cell lines and expression of mediators of angiogenesis and coagulation. Rath B, Plangger A, Klameth L, Hochmair M, Ulsperger E, Boeckx B, Neumayer C, Hamilton G. Explor Target Antitumor Ther. 2023 4(2):355-365. doi: 10.37349/etat.2023.00139.
Comparing maximum diameter and volume when assessing the growth of small abdominal aortic aneurysms using longitudinal CTA data: cohort study. Ristl R, Klopf J, Scheuba A, Sotir A, Wolf F, Domenig CM, Wanhainen A, Neumayer C, Posch M, Brostjan C, Eilenberg W. Int J Surg. 2023 Aug 1;109(8):2249-2257. doi: 10.1097/js9.0000000000000433.
Biomarkers of Spinal Cord Injury in Patients Undergoing Complex Endovascular Aortic Repair Procedures-A Narrative Review of Current Literature. Sotir A, Klopf J, Brostjan C, Neumayer C, Eilenberg W. Biomedicines. 2023 Apr 28;11(5). doi: 10.3390/biomedicines11051317.
Monoplane versus biplane fluoroscopy in patients undergoing fenestrated/branched endovascular aortic repair. Sotir A, Klopf J, Wolf F, Funovics MA, Loewe C, Domenig C, Kölbel T, Neumayer C, Eilenberg W. J Vasc Surg. 2023 May;77(5):1359-1366.e1352. doi: 10.1016/j.jvs.2022.12.037.
Early experience with bridging stent graft deployment without sheath support in branched and fenestrated endovascular aortic repair. Sotir A, Klopf J, Wolf F, Funovics MA, Loewe C, Kölbel T, Neumayer C, Eilenberg W. J Vasc Surg. 2023 Jun 16. doi: 10.1016/j.jvs.2023.05.054.
Soluble ST2 in Patients with Carotid Artery Stenosis-Association with Plaque Morphology and Long-Term Outcome. Stojkovic S, Kampf S, Harkot O, Nackenhorst M, Brekalo M, Huber K, Hengstenberg C, Neumayer C, Wojta J, Demyanets S. Int J Mol Sci. 2023 May 19;24(10). doi: 10.3390/ijms24109007.
Case Report: Auricular vagus nerve stimulation possibly alleviates COVID-19 disease on a high-risk patient. Széles JC, Lucny F, Tyercha A, Kaniusas E, Neumayer C. Front Physiol. 2022 13(1000194. doi: 10.3389/fphys.2022.1000194.
Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes. Theofilatos K, Stojkovic S, Hasman M, van der Laan SW, Baig F, Barallobre-Barreiro J, Schmidt LE, Yin S, Yin X, Burnap S, Singh B, Popham J, Harkot O, Kampf S, Nackenhorst MC, Strassl A, Loewe C, Demyanets S, Neumayer C, Bilban M, Hengstenberg C, Huber K, Pasterkamp G, Wojta J, Mayr M. Circ Res. 2023 Sep 15;133(7):542-558. doi: 10.1161/circresaha.123.322590.
Radiation and Chemotherapy are Associated with Altered Aortic Aneurysm Growth in Patients with Cancer: Impact of Synchronous Cancer and Aortic Aneurysm. Becker von Rose A, Kobus K, Bohmann B, Lindquist-Lilljequist M, Eilenberg W, Bassermann F, Reeps C, Eckstein HH, Trenner M, Maegdefessel L, Neumayer C, Brostjan C, Roy J, Hultgren R, Schwaiger BJ, Busch A. Eur J Vasc Endovasc Surg. 2022 Aug-Sep;64(2-3):255-264. doi: 10.1016/j.ejvs.2022.07.007.
Association of Lipoproteins with Neutrophil Extracellular Traps in Patients with Abdominal Aortic Aneurysm. Brandau A, Ibrahim N, Klopf J, Hayden H, Ozsvar-Kozma M, Afonyushkin T, Bleichert S, Fuchs L, Watzinger V, Nairz V, Manville E, Kessler V, Stangl H, Eilenberg W, Neumayer C, Brostjan C. Biomedicines. 2022 Jan 20;10(2). doi: 10.3390/biomedicines10020217.
The Femoral Vein as a Long-Term Aorto-Iliac Graft for Aortic Infection and Aortitis. Eilenberg W, Klopf J, Domenig CM, Klinger M, Wolf F, Gollackner B, Nanobachvili J, Neumayer C. World J Surg. 2022 May;46(5):1235-1242. doi: 10.1007/s00268-022-06460-w.
Interleukin-4 receptor alpha signaling regulates monocyte homeostasis. Haider P, Kral-Pointner JB, Salzmann M, Moik F, Bleichert S, Schrottmaier WC, Kaun C, Brekalo M, Fischer MB, Speidl WS, Hengstenberg C, Podesser BK, Huber K, Pabinger I, Knapp S, Brombacher F, Brostjan C, Ay C, Wojta J, Hohensinner PJ. Faseb j. 2022 Oct;36(10):e22532. doi: 10.1096/fj.202101672RR.
Use of a Steerable Sheath for Completely Femoral Access in Branched Endovascular Aortic Repair Compared to Upper Extremity Access. Hauck SR, Eilenberg W, Kupferthaler A, Kern M, Dachs TM, Wressnegger A, Neumayer C, Loewe C, Funovics MA. Cardiovasc Intervent Radiol. 2022 Jun;45(6):744-751. doi: 10.1007/s00270-022-03064-8.
3D Ultrasound Measurements Are Highly Sensitive to Monitor Formation and Progression of Abdominal Aortic Aneurysms in Mouse Models. Ibrahim N, Bleichert S, Klopf J, Kurzreiter G, Knöbl V, Hayden H, Busch A, Stiglbauer-Tscholakoff A, Eilenberg W, Neumayer C, Bailey MA, Brostjan C. Front Cardiovasc Med. 2022 9(944180. doi: 10.3389/fcvm.2022.944180.
Drug Treatment by Central Venous Catheter in a Mouse Model of Angiotensin II Induced Abdominal Aortic Aneurysm and Monitoring by 3D Ultrasound. Ibrahim N, Klopf J, Bleichert S, Bailey MA, Busch A, Stiglbauer-Tscholakoff A, Eilenberg W, Neumayer C, Brostjan C. J Vis Exp. 2022 Aug 4;186). doi: 10.3791/64124.
Circulating metabolites as a concept beyond tumor biology determining disease recurrence after resection of colorectal liver metastasis. Jonas JP, Hackl H, Pereyra D, Santol J, Ortmayr G, Rumpf B, Najarnia S, Schauer D, Brostjan C, Gruenberger T, Starlinger P. HPB (Oxford). 2022 Jan;24(1):116-129. doi: 10.1016/j.hpb.2021.06.415.
Peripheral Artery Disease Causes More Harm to Patients than COVID-19. Kasiri MM, Mittlboek M, Giurgea GA, Fortner N, Lirk P, Eilenberg W, Gollackner B, Neumayer C. Healthcare (Basel). 2022 Sep 20;10(10). doi: 10.3390/healthcare10101809.
AAA Revisited: A Comprehensive Review of Risk Factors, Management, and Hallmarks of Pathogenesis. Kessler V, Klopf J, Eilenberg W, Neumayer C, Brostjan C. Biomedicines. 2022 Jan 2;10(1). doi: 10.3390/biomedicines10010094.
Soluble ST2 as a Potential Biomarker for Abdominal Aortic Aneurysms-A Single-Center Retrospective Cohort Study. Klopf J, Demyanets S, Brekalo M, Eilenberg W, Wojta J, Neumayer C, Brostjan C, Stojkovic S. Int J Mol Sci. 2022 Aug 24;23(17). doi: 10.3390/ijms23179598.
The prognostic impact of vascular calcification on abdominal aortic aneurysm progression. Klopf J, Fuchs L, Schernthaner R, Domenig CM, Gollackner B, Brostjan C, Neumayer C, Eilenberg W. J Vasc Surg. 2022 Jun;75(6):1926-1934. doi: 10.1016/j.jvs.2021.11.062.
Towards Precritical Medical Therapy of the Abdominal Aortic Aneurysm. Musumeci L, Eilenberg W, Pincemail J, Yoshimura K, Sakalihasan N. Biomedicines. 2022 Nov 29;10(12). doi: 10.3390/biomedicines10123066.
The expression and role of tenascin C in abdominal aortic aneurysm formation and progression. Nagel F, Schaefer AK, Gonçalves IF, Acar E, Oszwald A, Kaiser P, Kain R, Trescher K, Eilenberg WH, Brostjan C, Santer D, Kiss A, Podesser BK. Interact Cardiovasc Thorac Surg. 2022 May 2;34(5):841-848. doi: 10.1093/icvts/ivac018.
Synergistic cytotoxicity of the CDK4 inhibitor Fascaplysin in combination with EGFR inhibitor Afatinib against Non-small Cell Lung Cancer. Plangger A, Rath B, Hochmair M, Funovics M, Neumayer C, Zeillinger R, Hamilton G. Invest New Drugs. 2022 Apr;40(2):215-223. doi: 10.1007/s10637-021-01181-8.
Growth prediction model for abdominal aortic aneurysms. Ristl R, Klopf J, Scheuba A, Wolf F, Funovics M, Gollackner B, Wanhainen A, Neumayer C, Posch M, Brostjan C, Eilenberg W. Br J Surg. 2022 Feb 1;109(2):211-219. doi: 10.1093/bjs/znab407.
Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment. Schimek V, Strasser K, Beer A, Göber S, Walterskirchen N, Brostjan C, Müller C, Bachleitner-Hofmann T, Bergmann M, Dolznig H, Oehler R. Cell Death Dis. 2022 Feb 4;13(2):113. doi: 10.1038/s41419-022-04585-3.
Left Renal Vein Division for Juxtarenal Aortic Exposure: Influence on Renal Function and Role of the Communicating Lumbar Vein. Selberherr A, Mari M, Klinger M, Burghuber C, Eilenberg W, Gollackner B, Neumayer C, Domenig C. World J Surg. 2022 Jun;46(6):1493-1499. doi: 10.1007/s00268-022-06480-6.
Case Report: Auricular vagus nerve stimulation possibly alleviates COVID-19 disease on a high-risk patient. Széles JC, Lucny F, Tyercha A, Kaniusas E, Neumayer C. Front Physiol. 2022 13(1000194. doi: 10.3389/fphys.2022.1000194.
Effects of metformin on human bone-derived mesenchymal stromal cell-breast cancer cell line interactions. Teufelsbauer M, Lang C, Plangger A, Rath B, Moser D, Staud C, Radtke C, Neumayer C, Hamilton G. Med Oncol. 2022 Feb 12;39(5):54. doi: 10.1007/s12032-022-01655-6.
Concomitantly discovered visceral artery aneurysms do rarely grow during cancer therapy. von Rose AB, Kobus K, Bohmann B, Trenner M, Wahida A, Eckstein HH, Bassermann F, von Heckel K, Wolk S, Reeps C, Schwaiger BJ, Eilenberg WH, Neumayer C, Burghuber C, Busch A. Clin Anat. 2022 Apr;35(3):296-304. doi: 10.1002/ca.23813.
Complement Factor C5a Is Increased in Blood of Patients with Abdominal Aortic Aneurysm and Has Prognostic Potential for Aneurysm Growth. Zagrapan B, Eilenberg W, Scheuba A, Klopf J, Brandau A, Story J, Dosch K, Hayden H, Domenig CM, Fuchs L, Schernthaner R, Ristl R, Huk I, Neumayer C, Brostjan C. J Cardiovasc Transl Res. 2021 Aug;14(4):761-769. doi: 10.1007/s12265-020-10086-5.
Low molecular weight heparin use in COVID-19 is associated with curtailed viral persistence-a retrospective multicenter observational study. Pereyra D, Heber S, Schrottmaier WC, Santol J, Pirabe A, Schmuckenschlager A, Kammerer K, Ammon D, Sorz T, Fritsch F, Hayden H, Pawelka E, Krüger P, Rumpf B, Traugott MT, Glaser P, Firbas C, Schörgenhofer C, Seitz T, Karolyi M, Pabinger I, Brostjan C, Starlinger P, Weiss G, Bellmann-Weiler R, Salzer HJF, Jilma B, Zoufaly A, Assinger A. Cardiovasc Res. 2021 Oct 5. doi: 10.1093/cvr/cvab308.
Neutrophil subpopulations and their activation potential in patients with antiphospholipid syndrome and healthy individuals. Mauracher LM, Krall M, Roiß J, Hell L, Koder S, Hofbauer TM, Gebhart J, Hayden H, Brostjan C, Ay C, Pabinger I. Rheumatology (Oxford). 2021 Apr 6;60(4):1687-1699. doi: 10.1093/rheumatology/keaa532.
Neutrophils as Regulators and Biomarkers of Cardiovascular Inflammation in the Context of Abdominal Aortic Aneurysms. Klopf J, Brostjan C, Neumayer C, Eilenberg W. Biomedicines. 2021 Sep 16;9(9). doi: 10.3390/biomedicines9091236.
Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease. Klopf J, Brostjan C, Eilenberg W, Neumayer C. Int J Mol Sci. 2021 Jan 8;22(2). doi: 10.3390/ijms22020559.
Circulating metabolites as a concept beyond tumor biology determining disease recurrence after resection of colorectal liver metastasis. Jonas JP, Hackl H, Pereyra D, Santol J, Ortmayr G, Rumpf B, Najarnia S, Schauer D, Brostjan C, Gruenberger T, Starlinger P. HPB (Oxford). 2021 Jun 24. doi: 10.1016/j.hpb.2021.06.415.
Abdominal aortic aneurysm and virus infection: A potential causative role for cytomegalovirus infection? Jabłońska A, Zagrapan B, Paradowska E, Neumayer C, Eilenberg W, Brostjan C, Klinger M, Nanobachvili J, Huk I. J Med Virol. 2021 Aug;93(8):5017-5024. doi: 10.1002/jmv.26901.
Polymorphisms in the IL-6 and TNF-α gene are associated with an increased risk of abdominal aortic aneurysm. Jabłońska A, Zagrapan B, Neumayer C, Eilenberg W, Scheuba A, Brostjan C, Demyanets S, Klinger M, Nanobachvili J, Huk I. Int J Cardiol. 2021 Apr 15;329(192-197. doi: 10.1016/j.ijcard.2020.12.051.
ELISA detection of MPO-DNA complexes in human plasma is error-prone and yields limited information on neutrophil extracellular traps formed in vivo. Hayden H, Ibrahim N, Klopf J, Zagrapan B, Mauracher LM, Hell L, Hofbauer TM, Ondracek AS, Schoergenhofer C, Jilma B, Lang IM, Pabinger I, Eilenberg W, Neumayer C, Brostjan C. PLoS One. 2021 16(4):e0250265. doi: 10.1371/journal.pone.0250265.
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms. Eilenberg W, Zagrapan B, Bleichert S, Ibrahim N, Knöbl V, Brandau A, Martelanz L, Grasl MT, Hayden H, Nawrozi P, Rajic R, Häusler C, Potolidis A, Schirwani N, Scheuba A, Klopf J, Teubenbacher P, Weigl MP, Kirchweger P, Beitzke D, Stiglbauer-Tscholakoff A, Panzenböck A, Lang I, Mauracher LM, Hell L, Pabinger I, Bailey MA, Scott DJA, Maegdefessel L, Busch A, Huk I, Neumayer C, Brostjan C. Transl Res. 2021 Jul;233(32-46. doi: 10.1016/j.trsl.2021.02.003.
Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility. Busch A, Pauli J, Winski G, Bleichert S, Chernogubova E, Metschl S, Winter H, Trenner M, Wiegering A, Otto C, Fischer J, Reiser J, Werner J, Roy J, Brostjan C, Knappich C, Eckstein HH, Paloschi V, Maegdefessel L. JCI Insight. 2021 Aug 9;6(15). doi: 10.1172/jci.insight.140364.
3D histopathology of human tumours by fast clearing and ultramicroscopy. Sabdyusheva Litschauer I, Becker K, Saghafi S, Ballke S, Bollwein C, Foroughipour M, Gaugeler J, Foroughipour M, Schavelová V, László V, Döme B, Brostjan C, Weichert W, Dodt HU. Sci Rep. 2020 Oct 19;10(1):17619. doi: 10.1038/s41598-020-71737-w.
The aptamer BT200 effectively inhibits von Willebrand factor (VWF) dependent platelet function after stimulated VWF release by desmopressin or endotoxin. Kovacevic KD, Buchtele N, Schoergenhofer C, Derhaschnig U, Gelbenegger G, Brostjan C, Zhu S, Gilbert JC, Jilma B. Sci Rep. 2020 Jul 7;10(1):11180. doi: 10.1038/s41598-020-68125-9.
TLR2 2029C/T and TLR3 1377C/T and -7C/A Polymorphisms Are Associated with the Occurrence of Abdominal Aortic Aneurysm. Jabłońska A, Zagrapan B, Neumayer C, Klinger M, Eilenberg W, Nanobachvili J, Paradowska E, Brostjan C, Huk I. J Immunol. 2020 Jun 1;204(11):2900-2909. doi: 10.4049/jimmunol.1901014.
Neutrophil Extracellular Traps Induce MCP-1 at the Culprit Site in ST-Segment Elevation Myocardial Infarction. Hofbauer TM, Ondracek AS, Mangold A, Scherz T, Nechvile J, Seidl V, Brostjan C, Lang IM. Front Cell Dev Biol. 2020 8(564169. doi: 10.3389/fcell.2020.564169.
Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets. Haider P, Kral-Pointner JB, Mayer J, Richter M, Kaun C, Brostjan C, Eilenberg W, Fischer MB, Speidl WS, Hengstenberg C, Huber K, Wojta J, Hohensinner P. Arterioscler Thromb Vasc Biol. 2020 Sep;40(9):2265-2278. doi: 10.1161/atvbaha.120.314883.
Differential Osteoprotegerin Kinetics after Stimulation with Desmopressin and Lipopolysaccharides In Vivo. Buchtele N, Kovacevic KD, Brostjan C, Schwameis M, Hayden H, Derhaschnig U, Firbas C, Jilma B, Schoergenhofer C. Thromb Haemost. 2020 Jul;120(7):1108-1115. doi: 10.1055/s-0040-1712448.
The role of neutrophil death in chronic inflammation and cancer. Brostjan C, Oehler R. Cell Death Discov. 2020 6(26. doi: 10.1038/s41420-020-0255-6.
A Novel Diagnostic and Prognostic Score for Abdominal Aortic Aneurysms Based on D-Dimer and a Comprehensive Analysis of Myeloid Cell Parameters. Zagrapan B, Eilenberg W, Prausmueller S, Nawrozi P, Muench K, Hetzer S, Elleder V, Rajic R, Juster F, Martelanz L, Hayden H, Klopf J, Inan C, Teubenbacher P, Weigl MP, Kirchweger P, Beitzke D, Jilma B, Wojta J, Bailey MA, Scott DJA, Huk I, Neumayer C, Brostjan C. Thromb Haemost. 2019 May;119(5):807-820. doi: 10.1055/s-0039-1679939.
Predicting Postoperative Liver Dysfunction Based on Blood-Derived MicroRNA Signatures. Starlinger P, Hackl H, Pereyra D, Skalicky S, Geiger E, Finsterbusch M, Tamandl D, Brostjan C, Grünberger T, Hackl M, Assinger A. Hepatology. 2019 Jun;69(6):2636-2651. doi: 10.1002/hep.30572.
The Combination of APRI and ALBI Facilitates Preoperative Risk Stratification for Patients Undergoing Liver Surgery After Neoadjuvant Chemotherapy. Pereyra D, Rumpf B, Ammann M, Perrodin SF, Tamandl D, Haselmann C, Stift J, Brostjan C, Laengle F, Beldi G, Gruenberger T, Starlinger P. Ann Surg Oncol. 2019 Mar;26(3):791-799. doi: 10.1245/s10434-018-07125-6.
Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis. Mussbacher M, Salzmann M, Brostjan C, Hoesel B, Schoergenhofer C, Datler H, Hohensinner P, Basílio J, Petzelbauer P, Assinger A, Schmid JA. Front Immunol. 2019 10(85. doi: 10.3389/fimmu.2019.00085.
Primary Human Fibroblasts in Culture Switch to a Myofibroblast-Like Phenotype Independently of TGF Beta. Baranyi U, Winter B, Gugerell A, Hegedus B, Brostjan C, Laufer G, Messner B. Cells. 2019 Jul 13;8(7). doi: 10.3390/cells8070721.
Perioperative von Willebrand factor dynamics are associated with liver regeneration and predict outcome after liver resection. Starlinger P, Pereyra D, Haegele S, Braeuer P, Oehlberger L, Primavesi F, Kohler A, Offensperger F, Reiberger T, Ferlitsch A, Messner B, Beldi G, Staettner S, Brostjan C, Gruenberger T. Hepatology. 2018 Apr;67(4):1516-1530. doi: 10.1002/hep.29651.
Neutrophil-Mediated Proteolysis of Thrombospondin-1 Promotes Platelet Adhesion and String Formation. Seif K, Alidzanovic L, Tischler B, Ibrahim N, Zagrapan B, Rauscher S, Salzmann M, Hell L, Mauracher LM, Budde U, Schmid JA, Jilma B, Pabinger I, Assinger A, Starlinger P, Brostjan C. Thromb Haemost. 2018 Dec;118(12):2074-2085. doi: 10.1055/s-0038-1675229.
Simvastatin Treatment Upregulates HO-1 in Patients with Abdominal Aortic Aneurysm but Independently of Nrf2. Piechota-Polanczyk A, Kopacz A, Kloska D, Zagrapan B, Neumayer C, Grochot-Przeczek A, Huk I, Brostjan C, Dulak J, Jozkowicz A. Oxid Med Cell Longev. 2018 2018(2028936. doi: 10.1155/2018/2028936.
Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients. Mauracher LM, Posch F, Martinod K, Grilz E, Däullary T, Hell L, Brostjan C, Zielinski C, Ay C, Wagner DD, Pabinger I, Thaler J. J Thromb Haemost. 2018 Mar;16(3):508-518. doi: 10.1111/jth.13951.
Elevated ADAMTS13 Activity is Associated with Poor Postoperative Outcome in Patients Undergoing Liver Resection. Haegele S, Fuxsteiner J, Pereyra D, Koeditz C, Rumpf B, Schuetz C, Schwarz C, Brostjan C, Gruenberger T, Starlinger P. Sci Rep. 2018 Nov 14;8(1):16823. doi: 10.1038/s41598-018-34794-w.
Grants
• 2023-2026: Austrian Science Fund (FWF) # P37183-B
• 2019-2024: Austrian Science Fund (FWF) # DOC 59-833
• 2014-2022: Austrian Science Fund (FWF) # F5409-B21
• 2015-2017: Medical Scientific Fund of the Mayor of the City of Vienna #15012 / W. Eilenberg
• 2013-2015: Austrian National Bank (Jubiläumsfonds) # 15104
• 2011-2014: Austrian Science Fund (FWF) # P23691-B13
• 2009-2010: Medical Scientific Fund of the Mayor of the City of Vienna #8064 / T. Grünberger
• 2009-2010: Amgen Research Grant
• 2008-2010: Austrian National Bank (Jubiläumsfonds) # 12678
• 2007-2011: Austrian Science Fund (FWF) # P20074-B13
• 2006-2008: Austrian National Bank (Jubiläumsfonds) # 12072 / S.F. Schoppmann
• 2004-2005: Medical Scientific Fund of the Mayor of the City of Vienna #2257 / S. Roka
• 2003-2007: Austrian National Bank (Jubiläumsfonds) # 10235
• 2003-2005: Austrian Federal Ministry for Education, Science and Culture (CLEXO) # 7
• 2000-2002: Austrian Science Fund (FWF) # 14203-GEN
Klinische Studien
a.o. Univ.-Prof. Dr. Christine BROSTJAN
Forschungslabor GefäßchirurgieTel.: +43 (0)1 40400-73514
christine.brostjan@meduniwien.ac.at
Anna Spiegel Center of Translational Research, Level 5
Gabriela LANGER
Sekretariat Forschungslabor Anna SpiegelTel.: +43 (0)1 40400-73745
gabriela.langer@meduniwien.ac.at
Mo-Fr 08:00 - 12:00
Anna Spiegel, Ebene 5, Raum 25.05.003